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Target
Histamine H4 receptor
Ligand
BDBM50304505
Substrate
n/a
Meas. Tech.
ChEMBL_603902 (CHEMBL1048581)
Ki
282±n/a nM
Citation
 Sander, K; Kottke, T; Tanrikulu, Y; Proschak, E; Weizel, L; Schneider, EH; Seifert, R; Schneider, G; Stark, H 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. Bioorg Med Chem 17:7186-96 (2009) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50304505
Synonyms:
CHEMBL594949 | N4-(3-Methylbenzyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine
Type:
Small organic molecule
Emp. Form.:
C17H24N6
Mol. Mass.:
312.4127
SMILES:
CN1CCN(CC1)c1cc(NCc2cccc(C)c2)nc(N)n1
Structure:
Search PDB for entries with ligand similarity: