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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50304819
Substrate
n/a
Meas. Tech.
ChEMBL_606255 (CHEMBL1069945)
EC50
755±n/a nM
Citation
 Liu, KK; Cornelius, P; Patterson, TA; Zeng, Y; Santucci, S; Tomlinson, E; Gibbons, C; Maurer, TS; Marala, R; Brown, J; Kong, JX; Lee, E; Werner, W; Wenzel, Z; Vage, C Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett 20:266-71 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-2C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50304819
Synonyms:
4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine | CHEMBL595554 | US10227357, Compound P-0232
Type:
Small organic molecule
Emp. Form.:
C10H13N5
Mol. Mass.:
203.2437
SMILES:
C1CN(CCN1)c1ncnc2[nH]ccc12
Structure:
Search PDB for entries with ligand similarity: