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Target
D(1A) dopamine receptor
Ligand
BDBM50306441
Substrate
n/a
Meas. Tech.
ChEMBL_609907 (CHEMBL1074769)
Ki
1±n/a nM
Citation
 Sasikumar, TK; Burnett, DA; Greenlee, WJ; Smith, M; Fawzi, A; Zhang, H; Lachowicz, JE Remote functionalization of SCH 39166: discovery of potent and selective benzazepine dopamine D1 receptor antagonists. Bioorg Med Chem Lett 20:832-5 (2010) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50306441
Synonyms:
11-chloro-12-hydroxy-7-methyl-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphtho[2,1-b]azepine-4-carbaldehyde O-phenyl oxime | CHEMBL605354
Type:
Small organic molecule
Emp. Form.:
C26H25ClN2O2
Mol. Mass.:
432.942
SMILES:
CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c(\C=N\Oc3ccccc3)cccc21 |r|
Structure:
Search PDB for entries with ligand similarity: