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TargetVoltage-gated potassium channel subunit Kv1.5
LigandBDBM50306895
Substrate/Competitorn/a
Meas. Tech.ChEMBL_608671
IC50>1000±n/a nM
Citation Lloyd, JFinlay, HJVacarro, WHyunh, TKover, ABhandaru, RYan, LAtwal, KConder, MLJenkins-West, TShi, HHuang, CLi, DSun, HLevesque, P Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers. Bioorg Med Chem Lett20:1436-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Voltage-gated potassium channel subunit Kv1.5
Name:Voltage-gated potassium channel
Synonyms:HK2 | HPCN1 | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel
Type:Enzyme
Mol. Mass.:67222.47
Organism:Homo sapiens (Human)
Description:P22460
Residue:613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDA
DSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQ
RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQ
SGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIF
EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG
SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII
DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL
QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTT
VGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQG
TQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL
YALCLDTSRETDL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50306895
NameBDBM50306895
Synonyms:(7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)(2-(pyridin-3-yl)pyrrolidin-1-yl)methanone | CHEMBL601248
TypeSmall organic molecule
Emp. Form.C23H21Cl2N5O
Mol. Mass.454.352
SMILESCC1=Nc2ccnn2C(C1C(=O)N1CCCC1c1cccnc1)c1ccc(Cl)c(Cl)c1 |t:1|
Structure
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n/a