Reaction Details Report a problem with these data
Target
Monoacylglycerol lipase ABHD6
Ligand
BDBM50307077
Substrate
n/a
Meas. Tech.
ChEMBL_609360 (CHEMBL1072746)
IC50
6960±n/a nM
Citation
 Long, JZ; Jin, X; Adibekian, A; Li, W; Cravatt, BF Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J Med Chem 53:1830-42 (2010) [PubMed]  Article 
Target
Name:
Monoacylglycerol lipase ABHD6
Synonyms:
ABHD6_MOUSE | Abh6 | Abhd6 | Abhydrolase Domain-Containing Protein 6 | Monoacylglycerol lipase ABHD6
Type:
Single-pass type II membrane protein; hydrolase
Mol. Mass.:
38216.17
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant Abh6 transiently transfected in COS-7 cells.
Residue:
336
Sequence:
MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYAHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIVGQVKRIHQFVECLKLNKKPFHLIGTSMGGHVAGVYAAYYPSDVCSLSLVCPAGLQYSTDNPFVQRLKELEESAAIQKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNSFYRKLFLEIVNEKSRYSLHENMDKIKVPTQIIWGKQDQVLDVSGADILAKSISNSQVEVLENCGHSVVMERPRKTAKLIVDFLASVHNTDNKKLN
  
Inhibitor
Name:
BDBM50307077
Synonyms:
4-Nitrophenyl 4-(Bis(3,4-dimethoxyphenyl)(hydroxy)methyl)-piperidine-1-carboxylate | CHEMBL599726
Type:
Small organic molecule
Emp. Form.:
C29H32N2O9
Mol. Mass.:
552.5724
SMILES:
COc1ccc(cc1OC)C(O)(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+]([O-])=O)c1ccc(OC)c(OC)c1
Structure:
Search PDB for entries with ligand similarity: