Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM50307086
Substrate
n/a
Meas. Tech.
ChEMBL_609359 (CHEMBL1072745)
IC50
50±n/a nM
Citation
 Long, JZ; Jin, X; Adibekian, A; Li, W; Cravatt, BF Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J Med Chem 53:1830-42 (2010) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL)
Type:
Hydrolase
Mol. Mass.:
33391.67
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells.
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
  
Inhibitor
Name:
BDBM50307086
Synonyms:
4-Nitrophenyl 4-(3-(Pyridin-2-yloxy)benzyl)piperazine-1-carboxylate | CHEMBL600429
Type:
Small organic molecule
Emp. Form.:
C23H22N4O5
Mol. Mass.:
434.4446
SMILES:
[O-][N+](=O)c1ccc(OC(=O)N2CCN(Cc3cccc(Oc4ccccn4)c3)CC2)cc1
Structure:
Search PDB for entries with ligand similarity: