Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50309481
Substrate
n/a
Meas. Tech.
ChEMBL_609500 (CHEMBL1071772)
EC50
>10000±n/a nM
Citation
 Beattie, D; Brearley, A; Brown, Z; Charlton, SJ; Cox, B; Fairhurst, RA; Fozard, JR; Gedeck, P; Kirkham, P; Meja, K; Nanson, L; Neef, J; Oakman, H; Spooner, G; Taylor, RJ; Turner, RJ; West, R; Woodward, H Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists. Bioorg Med Chem Lett 20:1219-24 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50309481
Synonyms:
CHEMBL592541 | N-((2S,3S,4R,5R)-5-(2-(2-(1-ethyl-1H-imidazol-4-yl)ethylamino)-6-(pentan-3-ylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)propionamide
Type:
Small organic molecule
Emp. Form.:
C25H39N9O3
Mol. Mass.:
513.6357
SMILES:
CCC(CC)Nc1nc(NCCc2cn(CC)cn2)nc2n(cnc12)[C@@H]1C[C@H](NC(=O)CC)[C@@H](O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: