Reaction Details Report a problem with these data
Target
B1 bradykinin receptor
Ligand
BDBM50309622
Substrate
n/a
Meas. Tech.
ChEMBL_610511 (CHEMBL1064982)
IC50
0.5±n/a nM
Citation
Schnatbaum, K; Schaudt, M; Stragies, R; Pfeifer, JR; Gibson, C; Locardi, E; Scharn, D; Richter, U; Kalkhof, H; Dinkel, K; Zischinsky, G Novel small molecule bradykinin B1 receptor antagonists. Part 3: hydroxyurea derivatives. Bioorg Med Chem Lett 20:1233-6 (2010) [PubMed] Article
More Info.:
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
Inhibitor
Name:
BDBM50309622
Synonyms:
3-((5'-chloro-3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1-(1,3-difluoropropan-2-yl)-1-hydroxyurea | CHEMBL599490
Type:
Small organic molecule
Emp. Form.:
C18H16ClF4N7O2
Mol. Mass.:
473.812
SMILES:
Cn1nnc(n1)-c1c(F)cc(Cl)cc1-c1cnc(CNC(=O)N(O)C(CF)CF)c(F)c1