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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50310078
Substrate
n/a
Meas. Tech.
ChEMBL_612206 (CHEMBL1074144)
Ki
1.29±n/a nM
Citation
 Rossi, D; Urbano, M; Pedrali, A; Serra, M; Zampieri, D; Mamolo, MG; Laggner, C; Zanette, C; Florio, C; Schepmann, D; Wuensch, B; Azzolina, O; Collina, S Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2). Bioorg Med Chem 18:1204-12 (2010) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50310078
Synonyms:
(R/S)-1-(3-(6-Methoxynaphthalen-2-yl)butyl)piperidine | CHEMBL597643
Type:
Small organic molecule
Emp. Form.:
C20H27NO
Mol. Mass.:
297.4345
SMILES:
COc1ccc2cc(ccc2c1)C(C)CCN1CCCCC1
Structure:
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