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Target
Histamine H3 receptor
Ligand
BDBM50127610
Substrate
n/a
Meas. Tech.
ChEMBL_612765 (CHEMBL1071591)
Ki
1.3±n/a nM
Citation
 Kobayashi, T; Watanabe, M; Yoshida, A; Yamada, S; Ito, M; Abe, H; Ito, Y; Arisawa, M; Shuto, S Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands. Bioorg Med Chem 18:1076-82 (2010) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50127610
Synonyms:
(1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane | 2-[2-(1H-Imidazol-4-yl)-cyclopropyl]-ethylamine | CHEMBL60716
Type:
Small organic molecule
Emp. Form.:
C8H13N3
Mol. Mass.:
151.2089
SMILES:
NCC[C@@H]1C[C@@H]1c1cnc[nH]1
Structure:
Search PDB for entries with ligand similarity: