Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCoagulation factor X/antithrombin III
LigandBDBM50310299
Substrate/Competitorn/a
Meas. Tech.ChEMBL_607976
IC50>300000±n/a nM
Citation El-Ayache, NCLi, SHWarnock, MLawrence, DAEmal, CD Novel bis-arylsulfonamides and aryl sulfonimides as inactivators of plasminogen activator inhibitor-1 (PAI-1). Bioorg Med Chem Lett20:966-70 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X/antithrombin III
Name:Coagulation factor X/antithrombin III
Synonyms:ATIII | Antithrombin-III | Antithrombin-III precursor
Type:PROTEIN
Mol. Mass.:52602.34
Organism:Homo sapiens
Description:ChEMBL_35871
Residue:464
Sequence:
MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEK
KATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFA
MTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFG
DKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAIN
ELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQ
VLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDG
FSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAV
VIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50310299
NameBDBM50310299
Synonyms:CHEMBL599342 | N,N'-(ethane-1,2-diyl)bis(N-ethyl-3,4-dimethoxybenzenesulfonamide)
TypeSmall organic molecule
Emp. Form.C22H32N2O8S2
Mol. Mass.516.628
SMILESCCN(CCN(CC)S(=O)(=O)c1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(OC)c(OC)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a