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Target
Prostaglandin D2 receptor 2
Ligand
BDBM50312283
Substrate
n/a
Meas. Tech.
ChEMBL_622647 (CHEMBL1104958)
EC50
11±n/a nM
Citation
 Liu, J; Wang, Y; Sun, Y; Marshall, D; Miao, S; Tonn, G; Anders, P; Tocker, J; Tang, HL; Medina, J Tetrahydroquinoline derivatives as CRTH2 antagonists. Bioorg Med Chem Lett 19:6840-4 (2009) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Homo sapiens (Human)
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM50312283
Synonyms:
(+/-)-cis-N-(1-benzoyl-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)-N-phenylacetamide | CHEMBL1080622 | N-((2S,4R)-1-benzoyl-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)-N-phenylacetamide
Type:
Small organic molecule
Emp. Form.:
C25H24N2O2
Mol. Mass.:
384.4703
SMILES:
C[C@H]1C[C@@H](N(C(C)=O)c2ccccc2)c2ccccc2N1C(=O)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: