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Target5-Hydroxytryptamine receptor 6 (5-HT6)
LigandBDBM50313131
Substrate/Competitorn/a
Meas. Tech.ChEMBL_616577
EC50 31±n/a nM
Citation Bernotas, RCAntane, SShenoy, RLe, VDChen, PHarrison, BLRobichaud, AJZhang, GMSmith, DSchechter, LE 3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT(6) receptor modulators. Bioorg Med Chem Lett20:1657-60 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-Hydroxytryptamine receptor 6 (5-HT6)
Name:5-Hydroxytryptamine receptor 6 (5-HT6)
Synonyms:5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46968.43
Organism:Homo sapiens (human)
Description:Cultured Hela cells expressing h5-HT6 receptors.
Residue:440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50313131
NameBDBM50313131
Synonyms:1-(1-ethylpiperidin-3-yl)-3-(phenylsulfonyl)-1H-indole | CHEMBL1081094
TypeSmall organic molecule
Emp. Form.C21H24N2O2S
Mol. Mass.368.492
SMILESCCN1CCCC(C1)n1cc(c2ccccc12)S(=O)(=O)c1ccccc1
Structure
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