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Reaction Details
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TargetAngiotensin II receptor
LigandBDBM50313240
Substrate/Competitorn/a
Meas. Tech.ChEMBL_617060
Ki 0.9±n/a nM
Citation Fillion, DLemieux, GBasambombo, LLLavigne, PGuillemette, GLeduc, REscher, E The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1. J Med Chem53:2063-75 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Angiotensin II receptor
Name:Angiotensin II receptor
Synonyms:AT1 | AT1AR | AT1BR | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:Protein
Mol. Mass.:41080.75
Organism:Homo sapiens (Human)
Description:P30556
Residue:359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50313240
NameBDBM50313240
Synonyms:CHEMBL1076633 | [Sar1,Tdf8]AngII
TypeSmall organic molecule
Emp. Form.C51H70F3N15O10
Mol. Mass.1110.1912
SMILESCC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)C1(N=N1)C(F)(F)F)C(O)=O |r,wU:44.44,57.60,4.4,20.21,wD:2.2,24.32,8.17,61.63,c:74,(7.79,3.66,;7.73,2.12,;9.03,1.3,;10.39,2.02,;8.97,-.22,;7.62,-.93,;6.31,-.11,;6.37,1.42,;4.95,-.81,;4.89,-2.36,;6.19,-3.18,;7.54,-2.48,;8.84,-3.32,;8.76,-4.86,;10.06,-5.69,;7.41,-5.56,;6.11,-4.73,;3.65,0,;2.28,-.72,;2.22,-2.27,;.97,.11,;-.39,-.61,;-1.69,.22,;-1.63,1.75,;-3.05,-.49,;-3.12,-2.04,;-1.82,-2.86,;-1.87,-4.4,;-.57,-5.22,;-.62,-6.75,;.68,-7.57,;-1.98,-7.48,;-4.35,.34,;-5.71,-.38,;-5.77,-1.92,;-7.01,.43,;-8.36,-.28,;-9.67,.55,;1.03,1.64,;2.39,2.36,;-.27,2.46,;10.28,-1.05,;10.22,-2.6,;11.63,-.34,;12.99,-1.1,;14.3,-.33,;14.29,1.21,;15.53,2.12,;15.04,3.58,;13.5,3.57,;13.04,2.1,;13,-2.66,;11.66,-3.45,;14.34,-3.4,;15.72,-2.76,;16.75,-3.87,;16.02,-5.2,;14.52,-4.91,;13.25,-5.78,;11.9,-5.04,;13.28,-7.32,;14.39,-8.38,;14.01,-9.87,;15.11,-10.95,;14.73,-12.44,;15.84,-13.51,;17.32,-13.09,;17.7,-11.6,;16.6,-10.53,;18.43,-14.17,;18.85,-15.65,;19.92,-14.54,;19.76,-13.38,;21.1,-14.14,;19.74,-11.84,;20.85,-12.29,;15.87,-7.97,;16.97,-9.04,;16.25,-6.48,)|
Structure
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