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Target
Cathepsin K
Ligand
BDBM50313509
Substrate
n/a
Meas. Tech.
ChEMBL_617674 (CHEMBL1101470)
IC50
>10000±n/a nM
Citation
 Rankovic, Z; Cai, J; Fradera, X; Dempster, M; Mistry, A; Mitchell, A; Long, C; Hamilton, E; King, A; Boucharens, S; Jamieson, C; Gillespie, J; Cumming, I; Uitdehaag, J; van Zeeland, M Dioxo-triazines as a novel series of cathepsin K inhibitors. Bioorg Med Chem Lett 20:1488-90 (2010) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50313509
Synonyms:
2-(biphenyl-3-yl)-3,5-dioxo-4-propyl-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile | CHEMBL1078872
Type:
Small organic molecule
Emp. Form.:
C19H16N4O2
Mol. Mass.:
332.3559
SMILES:
CCCn1c(=O)c(nn(-c2cccc(c2)-c2ccccc2)c1=O)C#N
Structure:
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