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Target
Histone deacetylase 1
Ligand
BDBM50314135
Substrate
n/a
Meas. Tech.
ChEMBL_623892 (CHEMBL1105415)
IC50
30±n/a nM
Citation
 Oger, F; Lecorgne, A; Sala, E; Nardese, V; Demay, F; Chevance, S; Desravines, DC; Aleksandrova, N; Le Guével, R; Lorenzi, S; Beccari, AR; Barath, P; Hart, DJ; Bondon, A; Carettoni, D; Simonneaux, G; Salbert, G Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short alkyl groups on the phenyl ring. J Med Chem 53:1937-50 (2010) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50314135
Synonyms:
CHEMBL1093359 | N-(3,4-Dimethylphenyl)-N'-hydroxyoctanediamide
Type:
Small organic molecule
Emp. Form.:
C14H20N2O3
Mol. Mass.:
264.3202
SMILES:
Cc1ccc(NC(=O)CCCCC(=O)NO)cc1C
Structure:
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