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Target
Histone deacetylase 3
Ligand
BDBM50314143
Substrate
n/a
Meas. Tech.
ChEMBL_623893 (CHEMBL1105416)
IC50
1750±n/a nM
Citation
 Oger, F; Lecorgne, A; Sala, E; Nardese, V; Demay, F; Chevance, S; Desravines, DC; Aleksandrova, N; Le Guével, R; Lorenzi, S; Beccari, AR; Barath, P; Hart, DJ; Bondon, A; Carettoni, D; Simonneaux, G; Salbert, G Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short alkyl groups on the phenyl ring. J Med Chem 53:1937-50 (2010) [PubMed]  Article 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50314143
Synonyms:
CHEMBL1093043 | N-(2,3-Dimethylphenyl)-N'-hydroxyoctanediamide
Type:
Small organic molecule
Emp. Form.:
C14H20N2O3
Mol. Mass.:
264.3202
SMILES:
Cc1cccc(NC(=O)CCCCC(=O)NO)c1C
Structure:
Search PDB for entries with ligand similarity: