Reaction Details Report a problem with these data
Target
Cathepsin S
Ligand
BDBM50314235
Substrate
n/a
Meas. Tech.
ChEMBL_624118 (CHEMBL1103449)
IC50
3460±n/a nM
Citation
Wiener, DK; Lee-Dutra, A; Bembenek, S; Nguyen, S; Thurmond, RL; Sun, S; Karlsson, L; Grice, CA; Jones, TK; Edwards, JP Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors. Bioorg Med Chem Lett 20:2379-82 (2010) [PubMed] Article
More Info.:
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
Inhibitor
Name:
BDBM50314235
Synonyms:
CHEMBL1090995 | rac-2-(5-(1-(3-(4-(3-methyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)propyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-2-(trifluoromethyl)phenylthio)-1-morpholinoethanone
Type:
Small organic molecule
Emp. Form.:
C31H40F3N7O5S2
Mol. Mass.:
711.818
SMILES:
Cc1noc(n1)C1CCN(CCCn2nc(c3CN(CCc23)S(C)(=O)=O)-c2ccc(c(SCC(=O)N3CCOCC3)c2)C(F)(F)F)CC1