Target
5-hydroxytryptamine receptor 2B
Ligand
BDBM50314617
Substrate
n/a
Meas. Tech.
ChEMBL_625152 (CHEMBL1115173)
Ki
>10000±n/a nM
Citation
 Liu, KKLefker, BADombroski, MAChiang, PCornelius, PPatterson, TAZeng, YSantucci, STomlinson, EGibbons, CPMarala, RBrown, JAKong, JXLee, EWerner, WWenzel, ZGiragossian, CChen, HCoffey, SB Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity. Bioorg Med Chem Lett 20:2365-9 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2B
Synonyms:
5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
54312.47
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
481
Sequence:
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
  
Inhibitor
Name:
BDBM50314617
Synonyms:
(2S,6R)-4-((3,5-dimethylisoxazol-4-yl)methoxy)-2,6-difluorobenzyl 2,6-dimethylpiperazine-1-carboxylate | CHEMBL1091452
Type:
Small organic molecule
Emp. Form.:
C20H25F2N3O4
Mol. Mass.:
409.427
SMILES:
C[C@H]1CNC[C@@H](C)N1C(=O)OCc1c(F)cc(OCc2c(C)noc2C)cc1F |r|
Structure:
Search PDB for entries with ligand similarity: