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Target
Bombesin receptor subtype-3
Ligand
BDBM50313751
Substrate
n/a
Meas. Tech.
ChEMBL_627762 (CHEMBL1116184)
EC50
101±n/a nM
Citation
 Liu, J; He, S; Jian, T; Dobbelaar, PH; Sebhat, IK; Lin, LS; Goodman, A; Guo, C; Guzzo, PR; Hadden, M; Henderson, AJ; Pattamana, K; Ruenz, M; Sargent, BJ; Swenson, B; Yet, L; Tamvakopoulos, C; Peng, Q; Pan, J; Kan, Y; Palyha, O; Kelly, TM; Guan, XM; Howard, AD; Marsh, DJ; Metzger, JM; Reitman, ML; Wyvratt, MJ; Nargund, RP Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity. Bioorg Med Chem Lett 20:2074-7 (2010) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS-3 | BRS3 | BRS3_HUMAN | Bombesin 3 | Bombesin like receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44424.45
Organism:
Homo sapiens (Human)
Description:
Bombesin 3 BRS3 HUMAN::P32247
Residue:
399
Sequence:
MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
  
Inhibitor
Name:
BDBM50313751
Synonyms:
4'-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)biphenyl-2-carboxylic acid | 4'-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)biphenyl-2-carboxylicacid | 4'-(2-(5-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)biphenyl-2-carboxylic acid | CHEMBL1089721
Type:
Small organic molecule
Emp. Form.:
C24H28N2O2
Mol. Mass.:
376.4913
SMILES:
CCC(C)(C)Cc1cnc(CCc2ccc(cc2)-c2ccccc2C(O)=O)[nH]1
Structure:
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