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Target
Poly [ADP-ribose] polymerase 2
Ligand
BDBM50300016
Substrate
n/a
Meas. Tech.
ChEMBL_626085 (CHEMBL1110690)
Ki
2±n/a nM
Citation
 Penning, TD; Zhu, GD; Gong, J; Thomas, S; Gandhi, VB; Liu, X; Shi, Y; Klinghofer, V; Johnson, EF; Park, CH; Fry, EH; Donawho, CK; Frost, DJ; Buchanan, FG; Bukofzer, GT; Rodriguez, LE; Bontcheva-Diaz, V; Bouska, JJ; Osterling, DJ; Olson, AM; Marsh, KC; Luo, Y; Giranda, VL Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor. J Med Chem 53:3142-53 (2010) [PubMed]  Article 
Target
Name:
Poly [ADP-ribose] polymerase 2
Synonyms:
(ARTD2 or PARP2) | ADPRT2 | ADPRTL2 | PARP2 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2)
Type:
Enzyme
Mol. Mass.:
66225.70
Organism:
Homo sapiens (Human)
Description:
Q9UGN5
Residue:
583
Sequence:
MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKDRTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
  
Inhibitor
Name:
BDBM50300016
Synonyms:
2-(4-(Pyridin-2-yl)phenyl)-1H-benzo[d]imidazole-4-carboxamide | 2-(4-pyridine-2-ylphenyl)-1H-benzimidazole-4-carboxamide | CHEMBL576423
Type:
Small organic molecule
Emp. Form.:
C19H14N4O
Mol. Mass.:
314.3407
SMILES:
NC(=O)c1cccc2[nH]c(nc12)-c1ccc(cc1)-c1ccccn1
Structure:
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