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TargetMitogen-activated protein kinase 14
LigandBDBM50315924
Substrate/Competitorn/a
Meas. Tech.ChEMBL_625728
IC50 188±n/a nM
Citation Tester, RTan, XLuedtke, GRNashashibi, ISchinzel, KLiang, WJung, JDugar, SLiclican, ATabora, JLevy, DEDo, S Amide-based inhibitors of p38alpha MAP kinase. Part 2: design, synthesis and SAR of potent N-pyrimidyl amides. Bioorg Med Chem Lett20:2560-3 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:p38 MAP kinase alpha/beta
Synonyms:n/a
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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  Blast E-value cutoff:
BDBM50315924
NameBDBM50315924
Synonyms:(S)-N-ethyl-N-(2-(1-phenylethylamino)pyrimidin-4-yl)benzo[b]thiophene-3-carboxamide | CHEMBL1093209
TypeSmall organic molecule
Emp. Form.C23H22N4OS
Mol. Mass.402.512
SMILESCCN(C(=O)c1csc2ccccc12)c1ccnc(N[C@@H](C)c2ccccc2)n1 |r|
Structure
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