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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50316966
Substrate
n/a
Meas. Tech.
ChEMBL_630117 (CHEMBL1113708)
Ki
32.1±n/a nM
Citation
 Fiorino, F; Severino, B; De Angelis, F; Perissutti, E; Magli, E; Frecentese, F; Esposito, A; Massarelli, P; Nencini, C; Santagada, V; Caliendo, G New 5-HT(1A) receptor ligands containing a N'-cyanoisonicotinamidine nucleus: synthesis and in vitro pharmacological evaluation. Bioorg Med Chem Lett 20:2978-82 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52852.05
Organism:
Rattus norvegicus (rat)
Description:
Rat cortex membranes 5-HT2A receptors.
Residue:
471
Sequence:
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
  
Inhibitor
Name:
BDBM50316966
Synonyms:
CHEMBL1086959 | N'-cyano-N-(3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)isonicotinamidine
Type:
Small organic molecule
Emp. Form.:
C21H23F3N6
Mol. Mass.:
416.4427
SMILES:
FC(F)(F)c1cccc(c1)N1CCN(CCCN=C(NC#N)c2ccncc2)CC1 |w:17.17|
Structure:
Search PDB for entries with ligand similarity: