Reaction Details Report a problem with these data
Target
Anthranilate synthase component 1
Ligand
BDBM50317142
Substrate
n/a
Meas. Tech.
ChEMBL_630881 (CHEMBL1113010)
Ki
80000±n/a nM
Citation
Ziebart, KT; Dixon, SM; Avila, B; El-Badri, MH; Guggenheim, KG; Kurth, MJ; Toney, MD Targeting multiple chorismate-utilizing enzymes with a single inhibitor: validation of a three-stage design. J Med Chem 53:3718-29 (2010) [PubMed] Article
More Info.:
Target
Name:
Anthranilate synthase component 1
Synonyms:
TRPE_SALTY | trpE
Type:
PROTEIN
Mol. Mass.:
57080.90
Organism:
Salmonella typhimurium
Description:
ChEMBL_630882
Residue:
520
Sequence:
MQTPKPTLELLTCDAAYRENPTALFHQVCGDRPATLLLESADIDSKDDLKSLLLVDSALRITALGDTVTIQALSDNGASLLPLLDTALPAGVENDVLPAGRVLRFPPVSPLLDEDARLCSLSVFDAFRLLQGVVNIPTQEREAMFFGGLFAYDLVAGFEALPHLEAGNNCPDYCFYLAETLMVIDHQKKSTRIQASLFTASDREKQRLNARLAYLSQQLTQPAPPLPVTPVPDMRCECNQSDDAFGAVVRQLQKAIRAGEIFQVVPSRRFSLPCPSPLAAYYVLKKSNPSPYMFFMQDNDFTLFGASPESSLKYDAASRQIEIYPIAGTRPRGRRADGTLDRDLDSRIELDMRTDHKELSEHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLVSRVVGELRHDLDALHAYRACMNMGTLSGAPKVRAMQLIADAEGQRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATVQAGAGIVLDSVPQSEADETRNKARAVLRAIATAHHAQETF
Inhibitor
Name:
BDBM50317142
Synonyms:
2-(3-((S)-5-((S)-1-amino-3-(3-hydroxy-4-nitrophenyl)-1-oxopropan-2-ylamino)-4-(3,5-dimethoxybenzamido)-5-oxopentylcarbamoyl)phenoxy)acetic acid | CHEMBL1094070
Type:
Small organic molecule
Emp. Form.:
C32H35N5O12
Mol. Mass.:
681.6466
SMILES:
COc1cc(OC)cc(c1)C(=O)N[C@@H](CCCNC(=O)c1cccc(OCC(O)=O)c1)C(=O)N[C@@H](Cc1ccc(c(O)c1)[N+]([O-])=O)C(N)=O |r|