Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM50318883
Substrate
n/a
Meas. Tech.
ChEMBL_633770 (CHEMBL1119720)
IC50
34.5±n/a nM
Citation
 Allen, JG; Fotsch, C; Babij, P Emerging targets in osteoporosis disease modification. J Med Chem 53:4332-53 (2010) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50318883
Synonyms:
CHEMBL1085282 | VEL-0230 | sodium(2S,3S)-3-((S)-1-isobutoxy-4-methylpentan-2-ylcarbamoyl)oxirane-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C14H24NO5
Mol. Mass.:
286.3446
SMILES:
CC(C)COC[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C([O-])=O |r|
Structure:
Search PDB for entries with ligand similarity: