Target
Histamine H4 receptor
Ligand
BDBM50319288
Substrate
n/a
Meas. Tech.
ChEMBL_634016 (CHEMBL1117989)
Ki
>10000±n/a nM
Citation
 Savall, BMEdwards, JPVenable, JDBuzard, DJThurmond, RHack, MMcGovern, P Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands. Bioorg Med Chem Lett 20:3367-71 (2010) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50319288
Synonyms:
(+/-)-2-(4-(3-(3,6-diazabicyclo[3.2.0]heptan-3-yl)propoxy)-2-methylphenyl)-5-fluoro-4-methyl-1H-benzo[d]imidazole | CHEMBL1082609
Type:
Small organic molecule
Emp. Form.:
C23H27FN4O
Mol. Mass.:
394.4851
SMILES:
Cc1cc(OCCCN2CC3CNC3C2)ccc1-c1nc2ccc(F)c(C)c2[nH]1
Structure:
Search PDB for entries with ligand similarity: