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TargetHistamine receptor (H3)
LigandBDBM50319545
Substrate/Competitorn/a
Meas. Tech.ChEMBL_634304
Ki 0.29±n/a nM
Citation Liu, HAltenbach, RJDiaz, GJManelli, AMMartin, RLMiller, TREsbenshade, TABrioni, JDCowart, MD In vitro studies on a class of quinoline containing histamine H3 antagonists. Bioorg Med Chem Lett20:3295-300 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine receptor (H3)
Name:Histamine receptor (H3 and H4)
Synonyms:G-protein coupled receptor 97 | HH3R | HISTAMINE H3 | HRH3 | Histamine H3 Receptor | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:48691.47
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50319545
NameBDBM50319545
Synonyms:2-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl)-6-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)quinoline | CHEMBL1086098
TypeSmall organic molecule
Emp. Form.C25H25F2N5
Mol. Mass.433.4963
SMILESC[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1nnn(c1C)-c1ccc(F)cc1F |r|
Structure
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