Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50319513
Substrate
n/a
Meas. Tech.
ChEMBL_634305 (CHEMBL1120718)
Ki
2.2±n/a nM
Citation
 Liu, H; Altenbach, RJ; Diaz, GJ; Manelli, AM; Martin, RL; Miller, TR; Esbenshade, TA; Brioni, JD; Cowart, MD In vitro studies on a class of quinoline containing histamine H3 antagonists. Bioorg Med Chem Lett 20:3295-300 (2010) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50319513
Synonyms:
(R)-2-(2,6-dimethylpyridin-3-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline | CHEMBL1082447
Type:
Small organic molecule
Emp. Form.:
C23H27N3
Mol. Mass.:
345.4806
SMILES:
C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1ccc(C)nc1C |r|
Structure:
Search PDB for entries with ligand similarity: