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TargetCyclin-dependent kinase 2
LigandBDBM50229973
Substrate/Competitorn/a
Meas. Tech.ChEMBL_634455
Ki 2±n/a nM
Citation Wang, SMidgley, CAScaërou, FGrabarek, JBGriffiths, GJackson, WKontopidis, GMcClue, SJMcInnes, CMeades, CMezna, MPlater, AStuart, IThomas, MPWood, GClarke, RGBlake, DGZheleva, DILane, DPJackson, RCGlover, DMFischer, PM Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors. J Med Chem53:4367-78 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 2
Name:Cyclin-dependent kinase 2
Synonyms:CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50229973
NameBDBM50229973
Synonyms:(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine | 4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)thiazol-2-amine | CHEMBL298445 | [4-(2-AMINO-4-METHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-(3-NITRO-PHENYL)-AMINE
TypeSmall organic molecule
Emp. Form.C14H12N6O2S
Mol. Mass.328.349
SMILESCc1nc(N)sc1-c1ccnc(Nc2cccc(c2)[N+]([O-])=O)n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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