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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50319842
Substrate
n/a
Meas. Tech.
ChEMBL_634905 (CHEMBL1120632)
Ki
2.4±n/a nM
Citation
 Colucci, J; Boyd, M; Berthelette, C; Chiasson, JF; Wang, Z; Ducharme, Y; Friesen, R; Wrona, M; Levesque, JF; Denis, D; Mathieu, MC; Stocco, R; Therien, AG; Clarke, P; Rowland, S; Xu, D; Han, Y Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain. Bioorg Med Chem Lett 20:3760-3 (2010) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50319842
Synonyms:
(S)-4-(1-(1-(3-chlorobenzyl)-5-fluoro-1H-indole-7-carboxamido)ethyl)benzoic acid | CHEMBL1085041
Type:
Small organic molecule
Emp. Form.:
C25H20ClFN2O3
Mol. Mass.:
450.889
SMILES:
C[C@H](NC(=O)c1cc(F)cc2ccn(Cc3cccc(Cl)c3)c12)c1ccc(cc1)C(O)=O |r|
Structure:
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