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Target
Cytochrome P450 2J2
Ligand
BDBM50319982
Substrate
n/a
Meas. Tech.
ChEMBL_635054 (CHEMBL1119168)
IC50
2700±n/a nM
Citation
 Kowalski, JA; Swinamer, AD; Muegge, I; Eldrup, AB; Kukulka, A; Cywin, CL; De Lombaert, S Rapid synthesis of an array of trisubstituted urea-based soluble epoxide hydrolase inhibitors facilitated by a novel solid-phase method. Bioorg Med Chem Lett 20:3703-7 (2010) [PubMed]  Article 
Target
Name:
Cytochrome P450 2J2
Synonyms:
CP2J2_HUMAN | CYP2J2
Type:
Enzyme
Mol. Mass.:
57623.04
Organism:
Homo sapiens (Human)
Description:
P51589
Residue:
502
Sequence:
MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAVPQV
  
Inhibitor
Name:
BDBM50319982
Synonyms:
CHEMBL1085746 | N-(2,4-dichlorobenzyl)-4-(pyridin-4-yloxy)piperidine-1-carboxamide
Type:
Small organic molecule
Emp. Form.:
C18H19Cl2N3O2
Mol. Mass.:
380.268
SMILES:
Clc1ccc(CNC(=O)N2CCC(CC2)Oc2ccncc2)c(Cl)c1
Structure:
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