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Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM50320938
Substrate
n/a
Meas. Tech.
ChEMBL_638041 (CHEMBL1166944)
IC50
4050±n/a nM
Citation
 Xu, JQ; Shen, Q; Li, J; Hu, LH Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphatase 1B. Bioorg Med Chem 18:3934-9 (2010) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM50320938
Synonyms:
(3S,20S,23S)-3-(2'-Methoxybenzoyloxy)-20,23-dihydroxydammar-24-en-21-oic acid-21,23-lactone | CHEMBL1163233
Type:
Small organic molecule
Emp. Form.:
C37H52O6
Mol. Mass.:
592.8052
SMILES:
[#6]-[#8]-c1ccccc1-[#6](=O)-[#8]-[#6@H]1-[#6]-[#6][C@@]2([#6])[#6@@H](-[#6]-[#6][C@@]3([#6])[#6@@H]-4-[#6]-[#6]-[#6@@H](-[#6@H]-4-[#6]-[#6]-[#6@H]23)[C@@]2([#8])[#6]-[#6@H](-[#8]-[#6]2=O)\[#6]=[#6](\[#6])-[#6])C1([#6])[#6] |r|
Structure:
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