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Target
Neutrophil elastase
Ligand
BDBM50321748
Substrate
n/a
Meas. Tech.
ChEMBL_641056 (CHEMBL1174297)
IC50
30.8±n/a nM
Citation
 Hsieh, PW; Yu, HP; Chang, YJ; Hwang, TL Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats. Eur J Med Chem 45:3111-5 (2010) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50321748
Synonyms:
5-Chloro-2-(2-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one | CHEMBL1172305
Type:
Small organic molecule
Emp. Form.:
C14H7ClFNO2
Mol. Mass.:
275.662
SMILES:
Fc1ccccc1-c1nc2cccc(Cl)c2c(=O)o1
Structure:
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