Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50321782
Substrate
n/a
Meas. Tech.
ChEMBL_641177 (CHEMBL1174684)
Ki
21.0±n/a nM
Citation
 Oberdorf, C; Schmidt, TJ; Wünsch, B 5D-QSAR for spirocyclic sigma1 receptor ligands by Quasar receptor surface modeling. Eur J Med Chem 45:3116-24 (2010) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50321782
Synonyms:
1-(cyclohexylmethyl)-1'-phenyl-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]pyrazole] | CHEMBL1171555
Type:
Small organic molecule
Emp. Form.:
C23H31N3O
Mol. Mass.:
365.5117
SMILES:
C(C1CCCCC1)N1CCC2(CC1)OCCc1c2cnn1-c1ccccc1
Structure:
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