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Target
Metallo-beta-lactamase type 2
Ligand
BDBM50322605
Substrate
n/a
Meas. Tech.
ChEMBL_641771 (CHEMBL1177094)
Ki
2000±n/a nM
Citation
 Lassaux, P; Hamel, M; Gulea, M; Delbrück, H; Mercuri, PS; Horsfall, L; Dehareng, D; Kupper, M; Frère, JM; Hoffmann, K; Galleni, M; Bebrone, C Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. J Med Chem 53:4862-76 (2010) [PubMed]  Article 
Target
Name:
Metallo-beta-lactamase type 2
Synonyms:
BLAB_AERHY | Beta-lactamase | cphA
Type:
PROTEIN
Mol. Mass.:
28022.56
Organism:
Aeromonas hydrophila
Description:
ChEMBL_641771
Residue:
254
Sequence:
MMKGWMKCGLAGAVVLMASFWGGSVRAAGMSLTQVSGPVYVVEDNYYVQENSMVYFGAKGVTVVGATWTPDTARELHKLIKRVSRKPVLEVINTNYHTDRAGGNAYWKSIGAKVVSTRQTRDLMKSDWAEIVAFTRKGLPEYPDLPLVLPNVVHDGDFTLQEGKVRAFYAGPAHTPDGIFVYFPDEQVLYGNCILKEKLGNLSFADVKAYPQTLERLKAMKLPIKTVIGGHDSPLHGPELIDHYEALIKAAPQS
  
Inhibitor
Name:
BDBM50322605
Synonyms:
CHEMBL1173337 | Diisopropyl 2-(sulfanylmethyl)phenylphosphonate | bis(1-methylethyl) [2-(sulfanylmethyl)phenyl]phosphonate
Type:
Small organic molecule
Emp. Form.:
C13H21O3PS
Mol. Mass.:
288.343
SMILES:
CC(C)OP(=O)(OC(C)C)c1ccccc1CS
Structure:
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