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Target
Cathepsin S
Ligand
BDBM50323247
Substrate
n/a
Meas. Tech.
ChEMBL_643891 (CHEMBL1211790)
IC50
84±n/a nM
Citation
 Cai, J; Baugh, M; Black, D; Long, C; Jonathan Bennett, D; Dempster, M; Fradera, X; Gillespie, J; Andrews, F; Boucharens, S; Bruin, J; Cameron, KS; Cumming, I; Hamilton, W; Jones, PS; Kaptein, A; Kinghorn, E; Maidment, M; Martin, I; Mitchell, A; Rankovic, Z; Robinson, J; Scullion, P; Uitdehaag, JC; Vink, P; Westwood, P; van Zeeland, M; van Berkom, L; Bastiani, M; Meulemans, T 6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors. Bioorg Med Chem Lett 20:4350-4 (2010) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM50323247
Synonyms:
6-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile | CHEMBL1209086 | US9115126, Reference imidazopyridine derivative from WO 2009/010491 - Example 2a
Type:
Small organic molecule
Emp. Form.:
C20H20F3N5O
Mol. Mass.:
403.4009
SMILES:
CN(C)CCCOc1ccc(cc1C(F)(F)F)-c1cc2n(C)cnc2c(n1)C#N
Structure:
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