Target
Cathepsin K
Ligand
BDBM50323270
Substrate
n/a
Meas. Tech.
ChEMBL_643890 (CHEMBL1211789)
IC50
2818±n/a nM
Citation
 Cai, JBaugh, MBlack, DLong, CJonathan Bennett, DDempster, MFradera, XGillespie, JAndrews, FBoucharens, SBruin, JCameron, KSCumming, IHamilton, WJones, PSKaptein, AKinghorn, EMaidment, MMartin, IMitchell, ARankovic, ZRobinson, JScullion, PUitdehaag, JCVink, PWestwood, Pvan Zeeland, Mvan Berkom, LBastiani, MMeulemans, T 6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors. Bioorg Med Chem Lett 20:4350-4 (2010) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50323270
Synonyms:
6-(4-(2-hydroxyethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile | CHEMBL1209857
Type:
Small organic molecule
Emp. Form.:
C16H11F3N4O2
Mol. Mass.:
348.2793
SMILES:
OCCOc1ccc(cc1C(F)(F)F)-c1cc2nc[nH]c2c(n1)C#N
Structure:
Search PDB for entries with ligand similarity: