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TargetCathepsin S
LigandBDBM50323258
Substrate/Competitorn/a
Meas. Tech.ChEMBL_643889
IC50 24±n/a nM
Citation Cai, JBaugh, MBlack, DLong, CJonathan Bennett, DDempster, MFradera, XGillespie, JAndrews, FBoucharens, SBruin, JCameron, KSCumming, IHamilton, WJones, PSKaptein, AKinghorn, EMaidment, MMartin, IMitchell, ARankovic, ZRobinson, JScullion, PUitdehaag, JCVink, PWestwood, Pvan Zeeland, Mvan Berkom, LBastiani, MMeulemans, T 6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors. Bioorg Med Chem Lett20:4350-4 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin S
Name:Cathepsin S
Synonyms:CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:Protein
Mol. Mass.:37507.38
Organism:Homo sapiens (Human)
Description:P25774
Residue:331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50323258
NameBDBM50323258
Synonyms:6-(4-(3-hydroxypropyl)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile | CHEMBL1208910 | US9115126, WO 2009/010491, Example 15
TypeSmall organic molecule
Emp. Form.C18H15F3N4O
Mol. Mass.360.3331
SMILESCn1cnc2c(nc(cc12)-c1ccc(CCCO)c(c1)C(F)(F)F)C#N
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a