Reaction Details Report a problem with these data
Target
Transmembrane protease serine 11D
Ligand
BDBM50323871
Substrate
n/a
Meas. Tech.
ChEMBL_647602 (CHEMBL1219953)
Ki
54.3±n/a nM
Citation
 Wysocka, M; Spichalska, B; Lesner, A; Jaros, M; Brzozowski, K; Łegowska, A; Rolka, K Substrate specificity and inhibitory study of human airway trypsin-like protease. Bioorg Med Chem 18:5504-9 (2010) [PubMed]  Article 
Target
Name:
Transmembrane protease serine 11D
Synonyms:
Airway trypsin-like protease | HAT | TM11D_HUMAN | TMPRSS11D | Transmembrane protease serine 11D catalytic chain | Transmembrane protease serine 11D non-catalytic chain
Type:
PROTEIN
Mol. Mass.:
46272.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_840134
Residue:
418
Sequence:
MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNVEYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKFQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI
  
Inhibitor
Name:
BDBM50323871
Synonyms:
(6S,9S,12S,15S)-1,20-diamino-12-(3-amino-3-oxopropyl)-15-(2-aminobenzamido)-9-(carboxymethyl)-1,20-diimino-8,11,14-trioxo-2,7,10,13,19-pentaazaicosane-6-carboxylic acid | CHEMBL1214092
Type:
Small organic molecule
Emp. Form.:
C28H44N12O9
Mol. Mass.:
692.724
SMILES:
NC(=N)NCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)c1ccccc1N)C(O)=O |r|
Structure:
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