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TargetPolycystin-2
LigandBDBM50324337
Substrate/Competitorn/a
Meas. Tech.ChEMBL_650175
IC50 60±n/a nM
Citation Meredith, ELBeattie, KBurgis, RCapparelli, MChapo, JDipietro, LGamber, GEnyedy, IHood, DBHosagrahara, VJewell, CKoch, KALee, WLemon, DDMcKinsey, TAMiranda, KPagratis, NPhan, DPlato, CRao, CRozhitskaya, OSoldermann, NSpringer, Cvan Eis, MVega, RBYan, WZhu, QMonovich, LG Identification of potent and selective amidobipyridyl inhibitors of protein kinase D. J Med Chem53:5422-38 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Polycystin-2
Name:Polycystin-2
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:109676.85
Organism:Homo sapiens (Human)
Description:ChEMBL_886731
Residue:968
Sequence:
MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIR
QAAARDPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEVEGEEGGMVVEMDVEWRP
GSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPL
EGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYG
MMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQ
TEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGP
RNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTR
ATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIF
CFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLE
DQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGF
AIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIY
FTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKN
TVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQMRD
DLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQ
VLVRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEI
HREQMERLVREELERWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGG
NGSSNVHV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50324337
NameBDBM50324337
Synonyms:2'-Cyclohexylamino-6-((R)-3-methylpiperazin-1-yl)[2,4']bipyridinyl-4-carboxylic Acid Amide | CHEMBL1215222
TypeSmall organic molecule
Emp. Form.C22H30N6O
Mol. Mass.394.5132
SMILESC[C@@H]1CN(CCN1)c1cc(cc(n1)-c1ccnc(NC2CCCCC2)c1)C(N)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a