Target
Dipeptidyl peptidase 8
Ligand
BDBM50324507
Substrate
n/a
Meas. Tech.
ChEMBL_649273 (CHEMBL1218971)
Ki
1.2±n/a nM
Citation
 Meng, WBrigance, RPChao, HJFura, AHarrity, TMarcinkeviciene, JO'Connor, SPTamura, JKXie, DZhang, YKlei, HEKish, KWeigelt, CATurdi, HWang, AZahler, RKirby, MSHamann, LG Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem 53:5620-8 (2010) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 8
Synonyms:
DPP8 | DPP8_HUMAN | DPRP-1 | DPRP1 | Dipeptidyl peptidase 8 (DPP-8) | Dipeptidyl peptidase 8 (DPP8) | Dipeptidyl peptidase 8/9 | Dipeptidyl peptidase IV-related protein 1 | Dipeptidyl peptidase VIII | Dipeptidyl peptidase VIII (DDP-VIII) | Prolyl dipeptidase DPP8
Type:
Enzyme
Mol. Mass.:
103342.62
Organism:
Homo sapiens (Human)
Description:
Q6V1X1
Residue:
898
Sequence:
MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI
  
Inhibitor
Name:
BDBM50324507
Synonyms:
6-(aminomethyl)-5-(2,4-dichlorophenyl)-N-(furan-2-ylmethyl)-N,7-dimethylimidazo[1,2-a]pyrimidine-2-carboxamide | CHEMBL1215301
Type:
Small organic molecule
Emp. Form.:
C21H19Cl2N5O2
Mol. Mass.:
444.314
SMILES:
CN(Cc1ccco1)C(=O)c1cn2c(c(CN)c(C)nc2n1)-c1ccc(Cl)cc1Cl |(7.65,-13.28,;6.88,-11.95,;5.34,-11.95,;4.57,-13.28,;5.34,-14.61,;4.29,-15.77,;2.91,-15.13,;3.06,-13.6,;7.66,-10.61,;6.89,-9.28,;9.19,-10.6,;10.1,-11.84,;11.56,-11.37,;12.89,-12.13,;14.23,-11.36,;15.57,-12.15,;16.91,-11.39,;14.23,-9.82,;15.57,-9.05,;12.89,-9.06,;11.56,-9.83,;10.1,-9.36,;12.89,-13.68,;11.55,-14.45,;11.55,-16,;12.89,-16.76,;12.9,-18.3,;14.22,-16,;14.22,-14.45,;15.56,-13.67,)|
Structure:
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