Reaction Details
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Prolyl hydroxylase EGLN2
Ligand
BDBM50324536
Substrate
n/a
Meas. Tech.
ChEMBL_649378 (CHEMBL1219076)
IC50
>100000±n/a nM
Citation
Hamada, S; Suzuki, T; Mino, K; Koseki, K; Oehme, F; Flamme, I; Ozasa, H; Itoh, Y; Ogasawara, D; Komaarashi, H; Kato, A; Tsumoto, H; Nakagawa, H; Hasegawa, M; Sasaki, R; Mizukami, T; Miyata, N Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors. J Med Chem 53:5629-38 (2010) [PubMed] Article More Info.:
Target
Name:
Prolyl hydroxylase EGLN2
Synonyms:
EGLN2 | EGLN2_HUMAN | EIT6 | Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1)
Type:
Protein
Mol. Mass.:
43657.01
Organism:
Homo sapiens (Human)
Description:
Q96KS0
Residue:
407
Sequence:
MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAGSGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRKWAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALDYIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
Inhibitor
Name:
BDBM50324536
Synonyms:
3-{[10-(Dimethylamino)decanoyl](hydroxy)amino}propanoicAcid Hydrochloride | CHEMBL1215520
Type:
Small organic molecule
Emp. Form.:
C15H30N2O4
Mol. Mass.:
302.4097
SMILES:
CN(C)CCCCCCCCCC(=O)N(O)CCC(O)=O
Structure:
