Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50324542
Substrate
n/a
Meas. Tech.
ChEMBL_649427 (CHEMBL1219125)
Ki
2.7±n/a nM
Citation
 Xiong, Y; Ullman, B; Choi, JS; Cherrier, M; Strah-Pleynet, S; Decaire, M; Dosa, PI; Feichtinger, K; Teegarden, BR; Frazer, JM; Yoon, WH; Shan, Y; Whelan, K; Hauser, EK; Grottick, AJ; Semple, G; Al-Shamma, H Synthesis and in vivo evaluation of phenethylpiperazine amides: selective 5-hydroxytryptamine(2A) receptor antagonists for the treatment of insomnia. J Med Chem 53:5696-706 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HTR2A | 5HT2A_CANLF | HTR2A
Type:
PROTEIN
Mol. Mass.:
52384.55
Organism:
Canis familiaris
Description:
ChEMBL_1361183
Residue:
470
Sequence:
MDVLFEDNAPLSPTTSSLMPSNGDPRLYGNDLNAGDANTSDAFNWTVDAENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDIIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKKDAKSTDNDYSMVALGKQHSEDAPTDNINTVNEKVSCV
  
Inhibitor
Name:
BDBM50324542
Synonyms:
2-[4-(4-Chloro-1-methyl-1H-pyrazole-3-carbonyl)piperazin-1-yl]-1-(4-fluorophenyl)ethanone | CHEMBL1214946
Type:
Small organic molecule
Emp. Form.:
C17H18ClFN4O2
Mol. Mass.:
364.802
SMILES:
Cn1cc(Cl)c(n1)C(=O)N1CCN(CC(=O)c2ccc(F)cc2)CC1
Structure:
Search PDB for entries with ligand similarity: