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TargetAdrenergic beta-2 receptor (beta2)
LigandBDBM50324854
Substrate/Competitorn/a
Meas. Tech.ChEMBL_651475
Ki 0.500000±n/a nM
Citation Beattie, DBradley, MBrearley, ACharlton, SJCuenoud, BMFairhurst, RAGedeck, PGosling, MJanus, DJones, DLewis, CMcCarthy, COakman, HStringer, RTaylor, RJTuffnell, A A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of beta2-adrenoceptor agonists as inhaled long-acting bronchodilators. Bioorg Med Chem Lett20:5302-7 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Adrenergic beta-2 receptor (beta2)
Name:Adrenergic beta-2 receptor (beta2)
Synonyms:ADRB2 | ADRB2R | ADRB2R, B2AR | B2AR | Beta-2 adrenergic receptor | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:n/a
Mol. Mass.:46461.69
Organism:Homo sapiens (Human)
Description:n/a
Residue:413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
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  Blast E-value cutoff:
BDBM50324854
NameBDBM50324854
Synonyms:7-((R)-2-((1R,2R)-2-(benzyloxy)cyclopentylamino)-1-hydroxyethyl)-4-hydroxybenzo[d]thiazol-2(3H)-one | CHEMBL1221680
TypeSmall organic molecule
Emp. Form.C21H24N2O4S
Mol. Mass.400.491
SMILESO[C@@H](CN[C@@H]1CCC[C@H]1OCc1ccccc1)c1ccc(O)c2[nH]c(=O)sc12 |r|
Structure
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n/a