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Target
Vasopressin V1b receptor
Ligand
BDBM50325847
Substrate
n/a
Meas. Tech.
ChEMBL_652648 (CHEMBL1225851)
IC50
210±n/a nM
Citation
 Letourneau, JJ; Riviello, CM; Li, H; Cole, AG; Ho, KK; Zanetakos, HA; Desai, H; Zhao, J; Auld, DS; Napier, SE; Thomson, FJ; Goan, KA; Morphy, JR; Ohlmeyer, MH; Webb, ML Identification and optimization of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V3 (V1b) receptor antagonists. Bioorg Med Chem Lett 20:5394-7 (2010) [PubMed]  Article 
Target
Name:
Vasopressin V1b receptor
Synonyms:
Avpr1b | V1BR_RAT | VASOPRESSIN V1B | Vasopressin V1b receptor | Vasopressin receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47104.48
Organism:
RAT
Description:
VASOPRESSIN V1B AVPR1B RAT::P48974
Residue:
425
Sequence:
MNSEPSWTATPSPGGTLPVPNATTPWLGRDEELAKVEIGILATVLVLATGGNLAVLLTLGRHGHKRSRMHLFVLHLALTDLGVALFQVLPQLLWDITYRFQGSDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLRQPSQSTYPLIAAPWLLAAILSLPQVFIFSLREVIQGSGVLDCWADFYFSWGPRAYITWTTMAIFVLPVAVLSACYGLICHEIYKNLKVKTQAGREERRGWRTWDKSSSSAVATAATRGLPSRVSSISTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDENAPNEDSTNVAFTISMLLGNLSSCCNPWIYMGFNSRLLPRSLSHHACCTGSKPQVHRQLSTSSLTSRRTTLLTHACGSPTLRLSLNLSLRAKPRPAGSLKDLEQVDGEATMETSIF
  
Inhibitor
Name:
BDBM50325847
Synonyms:
CHEMBL1223814 | N-(cyclopropylmethyl)-2-(6-(3-morpholinopropoxy)-4-oxo-2-phenylquinazolin-3(4H)-yl)acetamide
Type:
Small organic molecule
Emp. Form.:
C27H32N4O4
Mol. Mass.:
476.5674
SMILES:
O=C(Cn1c(nc2ccc(OCCCN3CCOCC3)cc2c1=O)-c1ccccc1)NCC1CC1
Structure:
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