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TargetAurora kinase B
LigandBDBM50326203
Substrate/Competitorn/a
Meas. Tech.ChEMBL_659351
EC50>1200±n/a nM
Citation Cee, VJSchenkel, LBHodous, BLDeak, HLNguyen, HNOlivieri, PRRomero, KBak, ABe, XBellon, SBush, TLCheng, ACChung, GCoats, SEden, PMHanestad, KGallant, PLGu, YHuang, XKendall, RLLin, MHMorrison, MJPatel, VFRadinsky, RRose, PERoss, SSun, JRTang, JZhao, HPayton, MGeuns-Meyer, SD Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor. J Med Chem53:6368-77 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase B
Name:Aurora kinase B
Synonyms:AIM-1 | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | Serine/threonine-protein kinase aurora B
Type:Protein
Mol. Mass.:39327.72
Organism:Homo sapiens (Human)
Description:Q96GD4
Residue:344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50326203
NameBDBM50326203
Synonyms:CHEMBL1243073 | N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-phenoxybenzamide
TypeSmall organic molecule
Emp. Form.C30H25N5O3
Mol. Mass.503.5512
SMILESCNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2cccc(Oc3ccccc3)c2)cc1C
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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