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TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
LigandBDBM50326986
Substrate/Competitorn/a
Meas. Tech.ChEMBL_663438
EC50 50110±n/a nM
Citation Melchiorre, MDel Lungo, MGuandalini, LMartini, EDei, SManetti, DScapecchi, STeodori, ESartiani, LMugelli, ACerbai, ERomanelli, MN Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers. J Med Chem53:6773-7 (2010) [PubMed]  Article
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Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Name:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Synonyms:BCNG-2 | Brain cyclic nucleotide-gated channel 2 | HAC-1 | Hyperpolarization-activated cation channel 1
Type:PROTEIN
Mol. Mass.:94741.48
Organism:Mus musculus
Description:ChEMBL_663438
Residue:863
Sequence:
MDARGGGGRPGDSPGTTPAPGPPPPPPPPAPPQPQPPPAPPPNPTTPSHPESADEPGPRA
RLCSRDSACTPGAAKGGANGECGRGEPQCSPEGPARGPKVSFSCRGAASGPSAAEEAGSE
EAGPAGEPRGSQASFLQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPY
SDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGI
VIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVR
FTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFL
VPMLQDFPSDCWVSINNMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLS
MIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHR
YQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQP
GDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTY
CRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLSSGVFNNQE
NAIIQEIVKYDREMVQQAELGQRVGLFPPPPPPQVTSAIATLQQAVAMSFCPQVARPLVG
PLALGSPRLVRRAPPGPLPPAASPGPPAASPPAAPSSPRAPRTSPYGVPGSPATRVGPAL
PARRLSRASRPLSASQPSLPHGVPAPSPAASARPASSSTPRLGPAPTARTAAPSPDRRDS
ASPGAASGLDPLDSARSRLSSNL
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BDBM50326986
NameBDBM50326986
Synonyms:3,3'-((2Z,2'Z)-4,4'-((S)-2-(3,4-dimethoxyphenyl)propylazanediyl)bis(but-2-ene-4,1-diyl))bis(7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one) | CHEMBL1253476
TypeSmall organic molecule
Emp. Form.C43H51N3O8
Mol. Mass.737.8803
SMILESCOc1ccc(cc1OC)[C@H](C)CN(C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O |r,c:20,42|
Structure
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n/a