Reaction Details Report a problem with these data
Target
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Ligand
BDBM50326985
Substrate
n/a
Meas. Tech.
ChEMBL_663436 (CHEMBL1250984)
EC50
106900±n/a nM
Citation
Melchiorre, M; Del Lungo, M; Guandalini, L; Martini, E; Dei, S; Manetti, D; Scapecchi, S; Teodori, E; Sartiani, L; Mugelli, A; Cerbai, E; Romanelli, MN Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers. J Med Chem 53:6773-7 (2010) [PubMed] Article
More Info.:
Target
Name:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Synonyms:
BCNG-1 | Bcng1 | Brain cyclic nucleotide-gated channel 1 | HAC-2 | HCN1_MOUSE | Hac2 | Hcn1 | Hyperpolarization-activated cation channel 2
Type:
PROTEIN
Mol. Mass.:
102447.84
Organism:
Mus musculus
Description:
ChEMBL_663436
Residue:
910
Sequence:
MEGGGKPNSASNSRDDGNSVFPSKAPATGPVAADKRLGTPPGGGAAGKEHGNSVCFKVDGGGGEEPAGSFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIPPINYPQMTALNCTSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPIQSPLATRTFHYASPTASQLSLMQQPQQQLPQSQVQQTQTQTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQTPGSSTPKNEVHKSTQALHNTNLTKEVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVAAVHSTGLQAGSRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAVQRESPSVLNTDPDAEKPRFASNL
Inhibitor
Name:
BDBM50326985
Synonyms:
3,3'-((2Z,2'Z)-4,4'-(3,4-dimethoxyphenethylazanediyl)bis(but-2-ene-4,1-diyl))bis(7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one) | CHEMBL1253477
Type:
Small organic molecule
Emp. Form.:
C42H49N3O8
Mol. Mass.:
723.8538
SMILES:
COc1ccc(CCN(C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC |c:14,36|