Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
LigandBDBM50326989
Substrate/Competitorn/a
Meas. Tech.ChEMBL_663438
EC50 2300±n/a nM
Citation Melchiorre, MDel Lungo, MGuandalini, LMartini, EDei, SManetti, DScapecchi, STeodori, ESartiani, LMugelli, ACerbai, ERomanelli, MN Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers. J Med Chem53:6773-7 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Name:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Synonyms:BCNG-2 | Brain cyclic nucleotide-gated channel 2 | HAC-1 | Hyperpolarization-activated cation channel 1
Type:PROTEIN
Mol. Mass.:94741.48
Organism:Mus musculus
Description:ChEMBL_663438
Residue:863
Sequence:
MDARGGGGRPGDSPGTTPAPGPPPPPPPPAPPQPQPPPAPPPNPTTPSHPESADEPGPRA
RLCSRDSACTPGAAKGGANGECGRGEPQCSPEGPARGPKVSFSCRGAASGPSAAEEAGSE
EAGPAGEPRGSQASFLQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPY
SDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGI
VIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVR
FTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFL
VPMLQDFPSDCWVSINNMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLS
MIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHR
YQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQP
GDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTY
CRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLSSGVFNNQE
NAIIQEIVKYDREMVQQAELGQRVGLFPPPPPPQVTSAIATLQQAVAMSFCPQVARPLVG
PLALGSPRLVRRAPPGPLPPAASPGPPAASPPAAPSSPRAPRTSPYGVPGSPATRVGPAL
PARRLSRASRPLSASQPSLPHGVPAPSPAASARPASSSTPRLGPAPTARTAAPSPDRRDS
ASPGAASGLDPLDSARSRLSSNL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50326989
NameBDBM50326989
Synonyms:3-((Z)-4-(((R)-2-(3,4-dimethoxyphenyl)propyl)(methyl)amino)but-2-enyl)-7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one | CHEMBL1253992
TypeSmall organic molecule
Emp. Form.C28H36N2O5
Mol. Mass.480.5958
SMILESCOc1ccc(cc1OC)[C@@H](C)CN(C)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O |r,c:21|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a
NameBDBM50326989
Synonyms:3-((Z)-4-(((R)-2-(3,4-dimethoxyphenyl)propyl)(methyl)amino)but-2-enyl)-7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one | CHEMBL1253992
TypeSmall organic molecule
Emp. Form.C28H36N2O5
Mol. Mass.480.5958
SMILESCOc1ccc(cc1OC)[C@@H](C)CN(C)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O |r,c:21|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: