Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM50327348
Substrate
n/a
Meas. Tech.
ChEMBL_664389 (CHEMBL1259538)
IC50
7.5±n/a nM
Citation
 Hare, AA; Leng, L; Gandavadi, S; Du, X; Cournia, Z; Bucala, R; Jorgensen, WL Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF). Bioorg Med Chem Lett 20:5811-4 (2010) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50327348
Synonyms:
3-(3-hydroxybenzyl)-6-methylbenzo[d]oxazol-2(3H)-one | CHEMBL1256233
Type:
Small organic molecule
Emp. Form.:
C15H13NO3
Mol. Mass.:
255.2686
SMILES:
Cc1ccc2n(Cc3cccc(O)c3)c(=O)oc2c1
Structure:
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